Genetic variants in anti-Mullerian hormone-related genes and breast cancer risk: results from the AMBER consortium.

ABSTRACT:

Purpose

Circulating anti-Müllerian hormone (AMH) levels are positively associated with time to menopause and breast cancer risk. We examined breast cancer associations with single nucleotide polymorphisms (SNPs) in the AMH gene or its receptor genes, ACVR1 and AMHR2, among African American women.

Methods

In the AMBER consortium, we tested 65 candidate SNPs, and 1130 total variants, in or near AMH, ACVR1, and AMHR2 and breast cancer risk. Overall, 3649 cases and 4230 controls contributed to analyses. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer were calculated using multivariable logistic regression.

Results

After correction for multiple comparisons (false-discovery rate of 5%), there were no statistically significant associations with breast ca

SUBMITTER: Nichols HB 

PROVIDER: S-EPMC7867570 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature