Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immune dysregulation, gastrointestinal dysfunction, and altered gut microbiome compositions.

Methods

We sought to better understand nonbehavioral features of ASD by determining molecular signatures in peripheral tissues through mass spectrometry methods (ultrahigh performance liquid chromatography-tandem mass spectrometry) with broad panels of identified metabolites. Herein, we compared the global metabolome of 231 plasma and 97 fecal samples from a large cohort of children with ASD and typically developing control chi

SUBMITTER: Needham BD 

PROVIDER: S-EPMC7867605 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature