Association Between Serum Iron Biomarkers and Breast Cancer.

ABSTRACT:

Background

Iron is both essential to life and potentially toxic at higher levels. Epidemiologic studies of iron and breast cancer are sparse, with substantial heterogeneity found in a recent meta-analysis. Evidence based on a comprehensive set of iron biomarkers and a large sample size could help clarify relationships between iron body stores and breast cancer risk.

Methods

A case-cohort sample of 6,008 women, including 3,011 incident cases, has been followed for a median of 7.9 years. We estimated breast cancer HRs with Cox models, including age as the primary time scale and including in turn iron, ferritin, percent transferrin saturation, and their first principal component (PC) both as categorical (quartiles) and continuous measures.

Results

Adjusted HRs for the hi

SUBMITTER: Von Holle A 

PROVIDER: S-EPMC7867615 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature