Semisynthesis of the Organoarsenical Antibiotic Arsinothricin.
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ABSTRACT:
SUBMITTER: Suzol SH
PROVIDER: S-EPMC7867689 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Semisynthesis of the Organoarsenical Antibiotic Arsinothricin.
Suzol Sazzad H SH Hasan Howlader A A Galván Adriana E AE Radhakrishnan Manohar M Wnuk Stanislaw F SF Rosen Barry P BP Yoshinaga Masafumi M
Journal of natural products 20200824 9
Arsinothricin [AST (<b>1</b>)], a new broad-spectrum organoarsenical antibiotic, is a nonproteinogenic analogue of glutamate that effectively inhibits glutamine synthetase. We report the chemical synthesis of an intermediate in the pathway to <b>1</b>, hydroxyarsinothricin [AST-OH (<b>2</b>)], which can be converted to <b>1</b> by enzymatic methylation catalyzed by the ArsM As(III) <i>S</i>-adenosylmethionine methyltransferase. This is the first report of semisynthesis of <b>1</b>, providing a s ...[more]
Similar Datasets
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