Quorum sensing-regulated functions of Serratia marcescens are reduced by eugenol.

ABSTRACT:

Background and objectives

Serratia marcescens has emerged as a nosocomial pathogen responsible for human infections, where antibiotic resistance further complicates the treatments. In S. marcescens, biofilm formation and virulence factor production are controlled via quorum sensing (QS) system. QS is a signaling system that enables gene regulation to control diverse physiological functions in bacteria. Essential oils have shown to be potential in diminishing the pathogenicity and virulence of drug-resistant bacteria. This study was performed to determine whether eugenol would affect QS system, biofilm formation and virulence factor production of S. marcescens.

Materials and methods

Biofilm formation, extracellular virulence factor production (hemolysin a

SUBMITTER: Fekrirad Z 

PROVIDER: S-EPMC7867707 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature