Salvage surgery after definitive chemoradiotherapy for patients with non-small cell lung cancer.

ABSTRACT: Definitive chemoradiotherapy (CRT) has been a standard of care for patients with unresectable stage III non-small cell lung cancer (NSCLC). However, locoregional recurrence occurs in about 30% of patients after definitive CRT. Recently, the addition of durvalumab as maintenance therapy has shown to improve the outcome of these patients. However, locoregional recurrence will still remain. "Salvage surgery" has been performed to achieve local control in clinical practice, although its clinical significance is unclear. In this review, we define salvage surgery as lung resection for local control of the tumor which was not planned initially, after failure or insufficient treatment effect of the initial CRT for locally advanced cancer and evaluated nine studies to gain some insights on its role

SUBMITTER: Hamada A 

PROVIDER: S-EPMC7867739 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature