Association between aspirin use and lung cancer incidence depends on high-frequency use, bodyweight, and age in U.S. adults.

ABSTRACT:

Background

Chemoprevention of cancer with aspirin is controversial as a primary prevention strategy. We sought to investigate the association between aspirin frequency and risk of lung cancer in The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

Methods

Using data from 101,722 participants in PLCO, we used a Cox regression model coupling with propensity score to detect the association between aspirin frequency and lung cancer risk.

Results

High-frequency aspirin use significantly increased risk of lung cancer by 28% compared to no use (HR =1.28; 95% CI, 1.14-1.45; P=3.37×10^-5), especially for current smoker (HR =1.30; 95% CI, 1.07-1.57; P=6.82×10^-3). However, the increased lung cancer risk due to high-frequency aspirin use

SUBMITTER: Dong X 

PROVIDER: S-EPMC7867785 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature