Clinical types of checkpoint inhibitor-related pneumonitis in lung cancer patients: a multicenter experience.

ABSTRACT:

Background

Checkpoint inhibitor-related pneumonitis (CIP) is not well classified according to clinical factors. We propose different clinical sub-types of CIP based on clinical factors and investigated the corresponding clinical features, treatments, and outcomes.

Methods

We conducted a multicenter retrospective study of patients with lung cancer (including non-small cell lung cancer and small cell lung cancer) who developed CIP. The clinical characteristics, radiologic features, treatments, and outcomes of CIP were analyzed.

Results

A total of 55 patients developed CIP and were classified into 3 groups as follows: 21 in the pure type (PT) group, 14 in the induced type (IT) group, and 20 in the mixed type (MT) group. The incidence of severe (grade 3-5) pneumonitis was

SUBMITTER: Lin X 

PROVIDER: S-EPMC7867788 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature