A prognostic nomogram for lung adenocarcinoma based on immune-infiltrating Treg-related genes: from bench to bedside.

ABSTRACT:

Background

Accumulating evidence suggests that lymphocyte infiltration in the tumor microenvironment is positively correlated with tumorigenesis and development, while the role of Tregs (regulatory T cells) has been controversial. Therefore, we attempted to discover the possible value of Tregs for lung adenocarcinoma (LUAD).

Methods

The gene-sequencing data of LUAD were applied from three Gene Expression Omnibus (GEO) datasets-GSE10072, GSE32863 and GSE43458; the corresponding fractions of tumor-infiltrating immune cells were extracted from the CIBERSORTx portal. Weighted gene coexpression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis were conducted to identify the significant module and candidate genes related to Tregs. The role of candidat

SUBMITTER: Wang X 

PROVIDER: S-EPMC7867791 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature