Chemoradiation as a nonsurgical treatment option for early-stage esophageal cancers: a retrospective cohort study.

ABSTRACT:

Background

Complete tumor removal via esophagectomy or endoscopic excision has been associated with the greatest survival in early-stage esophageal cancer. However, patient health, anatomy, or goals of care may render patients ineligible for excision or resection. In this setting, chemoradiation (CRT) may be considered as a nonsurgical approach, however the outcomes associated with CRT in early-stage esophageal cancer are incompletely understood.

Methods

The National Cancer Database was queried for treatment-naïve cT1/T2, N0, M0 esophageal cancer patients managed with concurrent multi-agent CRT (≥50 Gy) between 2004 and 2015. Medically inoperable patients were excluded. Kaplan-Meier curves were generated to estimate 5-year overall survival (OS) from diagnosis in both stages.

SUBMITTER: Pathak R 

PROVIDER: S-EPMC7867841 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature