Analysis of the autoimmune response against BP180 in patients with Alzheimer's disease.

ABSTRACT:

Background

Current epidemiological studies suggest a significant correlation between Alzheimer's disease (AD) and bullous pemphigoid (BP). However, the autoimmune response against BP180 in patients with AD has not been fully understood. investigated.

Methods

We randomly enrolled 48 patients with AD and 50 sex- and age-matched healthy controls. We detected the presence/absence and the level of anti-BP180/BP230 immunoglobulin G (IgG) autoantibodies in the patients' serum to determine whether said antibodies possess reactivity against the BP180 protein in the human brain and skin.

Results

The enzyme-linked immunosorbent assay (ELISA) results revealed that the positive rate of anti-BP180 autoantibodies in patients with AD (23/48, 47.9%) was significantly higher than that

SUBMITTER: Wang YN 

PROVIDER: S-EPMC7867912 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature