Co-existence of myopia and amblyopia in a guinea pig model with monocular form deprivation.

ABSTRACT:

Background

Form deprivation myopia is a type of ametropia, with identifiable causes in humans, that has been induced in many animals. The age of onset of myopia induced by monocular form deprivation coincides with the period of visual development in guinea pigs. However, visual acuity of form-deprived eyes in guinea pigs is not understood yet. In this study, we investigated whether monocular form deprivation would affect visual acuity in infant guinea pigs by evaluating the development of myopia and amblyopia after monocular form deprivation, and whether form deprivation myopia and amblyopia occurred simultaneously or successively.

Methods

Twenty pigmented guinea pigs (2 weeks old) were randomly assigned to two groups: monocularly form-deprived (n=10), in which facemasks mod

SUBMITTER: Tian L 

PROVIDER: S-EPMC7867913 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature