Sirtuin 2 expression levels may predict the progression of sepsis survivors to chronic critical illness.

ABSTRACT:

Background

Sirtuin 2 (SIRT2) is a conserved deacetylase that participates in the regulation of inflammation in sepsis. In this observational prospective study, we investigated the predictive value of the SIRT2 expression level in the development of chronic critical illness (CCI) in patients with sepsis.

Methods

A total of 128 critically ill patients with sepsis or septic shock were enrolled and assigned to the CCI group, rapid recovery (RAP) group, or early death group according to their clinical trajectories. Patients' demographic and clinical information, as well as laboratory data, including C-reactive protein (CRP) level and total lymphocyte counts, were collected. Blood samples were obtained at admission and on days 1, 4, 7, 10, 14, and 21 (days 14 and 21

SUBMITTER: Xu H 

PROVIDER: S-EPMC7867923 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature