Stress-related hormone reduces autophagy through the regulation of phosphatidylethanolamine in breast cancer cells.

ABSTRACT:

Background

An increasing number of studies indicate that adrenergic signaling plays a fundamental role in tumor progression and metastasis induced by chronic stress. However, despite the growing attention, an understanding of the mechanisms linking chronic stress and cancer is still insufficient.

Methods

Western blot analysis and transmission electron microscopy (TEM) were used to observe the changes in autophagy level in a breast cancer cell line (MCF-7) after epinephrine treatment. Non-targeted metabolomics was also used to detect MCF-7 metabolites after epinephrine treatment. The xenograft model was used to detect the level of autophagy after epinephrine intervention.

Results

The results showed that epinephrine treatment reduced the autophagy level of breast cancer

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7867925 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature