Actin-granule formation is an additional step in cardiac myofibroblast differentiation.

ABSTRACT:

Background

Atrial fibrillation is the most common and long-lasting cardiac arrhythmia, and profoundly effects the daily lives of patients. The pathogenesis and persistence of atrial fibrillation is closely related to the cardiac fibroblast and its myofibroblast differentiation as increased collagen synthesis and migration capability. Thus better understanding of myofibroblast differentiation is essential for the prevention and treatment of atrial fibrillation.

Methods

Cardiac fibroblasts were isolated from neonatal rats and its actin structure was analyzed by immunofluorescence staining. Myofibroblast differentiation was induced by Angiotensin II (Ang II) and ROCK signaling related proteins were determined by western blot. Fasudil and Ricolinostat were employed to abrogate R

SUBMITTER: He L 

PROVIDER: S-EPMC7867932 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature