Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2.

ABSTRACT:

Background

The combined effects of glyphosate and hard water on chronic kidney disease of unknown etiology (CDKu) have attracted much interest, but the mechanisms remain unknown. Cytoplasmic phospholipase A₂ (cPLA₂) plays a key role in the acute and chronic inflammatory reactions. This study explored the effect of glyphosate combined with hard water on renal tubules and the possible targets and mechanisms involved.

Methods

In vivo experiments were conducted to investigate the synergistic effects and potential mechanisms of glyphosate and hard water on renal tubular injury in mice.

Results

Administration of glyphosate in mice resulted in elevated levels of β2-microglobulin (β₂-MG), albumin (ALB), and serum creatinine (SCr) compar

SUBMITTER: Wang R 

PROVIDER: S-EPMC7867956 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature