[Association between root abnormalities and related pathogenic genes in patients with generalized aggressive periodontitis].

ABSTRACT:

Objective

To explore the association between the abnormal root morphology and bone metabolism or root development related gene polymorphism in patients with generalized aggressive periodontitis.

Methods

In the study, 179 patients with generalized aggressive periodontitis were enrolled, with an average age of (27.23±5.19) years, male / female = 67/112. The average number of teeth remaining in the mouth was (26.80±1.84). Thirteen single nucleotide polymorphisms (SNPs) of nine genes which related to bone metabolism and root development were detected by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Root abnormalities were identified using periapical radiographs. The abnormal root morphology included cone-rooted teeth, slender-root t

SUBMITTER: Liu J 

PROVIDER: S-EPMC7867985 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature