Brainstem Volumetric Integrity in Preclinical and Prodromal Alzheimer's Disease.

ABSTRACT:

Background

Neuropathological studies have suggested the tau pathology observed in Alzheimer's disease (AD) originates in brainstem nuclei, but no studies to date have quantified brainstem volumes in clinical populations with biomarker-confirmed mild cognitive impairment (MCI) or dementia due to AD or determined the value of brainstem volumetrics in predicting dementia.

Objective

The present study examined whether MRI-based brainstem volumes differ among cognitively normal older adults and those with MCI or dementia due to AD and whether preclinical brainstem volumes predict future progression to dementia.

Methods

Alzheimer's Disease Neuroimaging Initiative participants (N = 1,629) underwent baseline MRI scanning with variable clinical follow-up (6-120 months). Region

SUBMITTER: Dutt S 

PROVIDER: S-EPMC7868064 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature