DNA methylome signatures as epigenetic biomarkers of hexanal associated with lung toxicity.

ABSTRACT:

Background

Numerous studies have investigated the relationship of environmental exposure, epigenetic effects, and human diseases. These linkages may contribute to the potential toxicity mechanisms of environmental chemicals. Here, we investigated the epigenetic pulmonary response of hexanal, a major indoor irritant, following inhalation exposure in F-344 rats.

Methods

Based on DNA methylation profiling in gene promoter regions, we identified hexanal-characterized methylated sites and target genes using an unpaired t-test with a fold-change cutoff of ≥ 3.0 and a p-value < 0.05. We also conducted an integrated analysis of DNA methylation and mRNA expression data to identify core anti-correlated target genes of hexanal exposure. To further investigate the potential key b

SUBMITTER: Cho Y 

PROVIDER: S-EPMC7868067 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature