Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases.

ABSTRACT: The concept of trained immunity has recently emerged as a mechanism contributing to several immune mediated inflammatory conditions. Trained immunity is defined by the immunological memory developed in innate immune cells after a primary non-specific stimulus that, in turn, promotes a heightened inflammatory response upon a secondary challenge. The most characteristic changes associated to this process involve the rewiring of cell metabolism and epigenetic reprogramming. Under physiological conditions, the role of trained immune cells ensures a prompt response. This action is limited by effective resolution of inflammation and tissue repair in order to restore homeostasis. However, unrestrained activation of innate immune cells contributes to the development of chronic inflammation and tis

SUBMITTER: Municio C 

PROVIDER: S-EPMC7868395 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature