Functional Prediction of Long Noncoding RNAs in Cutaneous Melanoma Using a Systems Biology Approach.

ABSTRACT: Cutaneous melanoma is the most aggressive type of skin cancer which its incidence has significantly increased in recent years worldwide. Thus, more investigations are required to identify the underlying mechanisms of melanoma malignant transformation and metastasis. In this context, long noncoding RNAs (lncRNAs) are a new type of noncoding transcripts that their dysregulations are associated with almost all cancers including melanoma. However, the precise functional roles of most of the significantly altered lncRNAs in melanoma have not yet been fully inspected. In this study, a comprehensive list of lncRNAs was interrogated across cutaneous melanoma samples to identify the significantly altered/dysregulated lncRNAs. To this end, lncRNAs were filtered in several steps and the selected lncR

SUBMITTER: Shahmoradi M 

PROVIDER: S-EPMC7868446 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature