Improved survival in several cancers with use of H₁-antihistamines desloratadine and loratadine.

ABSTRACT:

Background

We have previously shown an association with substantially improved survival in breast cancer and melanoma for desloratadine and loratadine users, and set out to find whether an improved survival can be seen in tumors with and without a known response to immune checkpoint therapy, such as anti-CTLA-4 or anti-PD-1.

Methods

We investigated survival and use of six common H₁-antihistamines (cetirizine, clemastine, desloratadine, ebastine, fexofenadine and loratadine) in a nation-wide cohort of all 429,198 Swedish patients with ten types of immunogenic (gastric, colorectal/anal, pancreatic, lung, breast, prostate, kidney, and bladder cancer, melanoma and Hodgkin lymphoma) and six non-immunogenic (liver, uterine, ovarian, brain/CNS, and thyroid cancer and non

SUBMITTER: Fritz I 

PROVIDER: S-EPMC7868613 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature