Prevalence of methylenetetrahydrofolate reductase gene polymorphisms (C677T, and A1298C) among Saudi children receiving dental treatment.

ABSTRACT:

Background

Methylenetetrahydrofolate reductase, the encoded by the MTHFR gene, plays a crucial role in converting the amino acid homocysteine to methionine. Two polymorphisms of the MTHFR gene, C677T and A1298C, reportedly reduce enzyme activity, resulting in hyperhomocysteinemia. Patients with C677T and A1298C polymorphisms may be at higher risk for developing abnormal hyperhomocysteinemia, which has been linked to catastrophic neurological including fatal outcomes.

Objective

Determine the prevalence of the MTHFR gene variants C677T and A1298C among pediatric dental patients treated at King Abdulaziz University Hospital.

Design

Cross-sectional.

Setting

Clinics of pediatric dentistry department.

Subjects and methods

Healthy Saudi chi

SUBMITTER: Bagher AM 

PROVIDER: S-EPMC7868620 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature