Adverse muscle composition is linked to poor functional performance and metabolic comorbidities in NAFLD.

ABSTRACT:

Background & aims

Sarcopenia and frailty are recognised as important factors in later stages of liver disease. However, their role in non-alcoholic fatty liver disease (NAFLD) is not yet fully understood. In this study we investigate the associations of MRI-measured adverse muscle composition (AMC: low muscle volume and high muscle fat) with poor function, sarcopenia, and metabolic comorbidity within NAFLD in the large UK Biobank imaging study.

Methods

A total of 9,545 participants were included. Liver fat, fat-tissue free muscle volume, and muscle fat infiltration were quantified using a rapid MRI protocol and automated image analysis (AMRA® Researcher). For each participant, a personalised muscle volume z-score (sex- and body size-specific) was calculated and combined with

SUBMITTER: Linge J 

PROVIDER: S-EPMC7868647 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature