COVID-19: molecular pathophysiology, genetic evolution and prospective therapeutics-a review.

ABSTRACT: The Covid-19 pandemic is highly contagious and has spread rapidly across the globe. To date there have been no specific treatment options available for this life-threatening disease. During this medical emergency, target-based drug repositioning/repurposing with a continuous monitoring and recording of results is an effective method for the treatment and drug discovery. This review summarizes the recent findings on COVID-19, its genomic organization, molecular evolution through phylogenetic analysis and has recapitulated the drug targets by analyzing the viral molecular machinery as drug targets and repurposing of most frequently used drugs worldwide and their therapeutic applications in COVID-19. Data from solidarity trials have shown that the treatment with Chloroquine, hydroxychloroquin

SUBMITTER: Raj CTD 

PROVIDER: S-EPMC7868660 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature