HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling.

ABSTRACT:

Aims

The elevated expression of phospholamban (PLB) has been observed in heart failure and cardiac remodelling, inhibiting the affinity of Ca2+ pump to Ca2+ thereby impairing heart relaxation. However, the mechanisms underlying the regulation of PLB remains to be further studied. The present study aims to test the role of RNA-binding protein HuR in the regulation of PLB and the impact of this regulatory process in cardiac remodelling.

Methods and results

A mouse model specifically deleted HuR in cardiomyocytes were used for testing the role of HuR in regulating PLB during isoproterenol (ISO)-induced cardiac remodelling. HuR deficiency did not significantly influence the phenotype and function of mouse heart under static status. However, deletion of HuR in cardiomyocytes miti

SUBMITTER: Hu H 

PROVIDER: S-EPMC7868665 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature