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Long intergenic non-coding RNA (lincRNA)-01317 suppresses human gastric cancer growth by inhibiting migration and invasion of cancer cells.

ABSTRACT: Long intergenic noncoding RNAs (lincRNAs) are strongly associated with several kinds of cancer, including gastric cancer. Here, we found significantly decreased lincRNA-01317 levels in cancer tissue compared with paracancer tissue of patients with gastric cancer, and lincRNA-01317 expression levels positively correlated with clinical survival rate. Furthermore, using a gastric cancer cell line and a xenograft mouse model, we found that transfection of a gastric cancer cell line with lincRNA-01317 significantly inhibited the proliferation, migration, and invasion of gastric cancer cells. Finally, we demonstrated that lincRNA-01317 may target KCNQ1, as KCNQ1 was downregulated after transfection of cells with lincRNA-01317. This study aimed to assess lincRNA-01317 as a potential therapeutic target to treat cancers.

SUBMITTER: Chen Y

PROVIDER: S-EPMC7868834 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Long intergenic non-coding RNA (lincRNA)-01317 suppresses human gastric cancer growth by inhibiting migration and invasion of cancer cells.

Chen Yong Y Zhang Kundong K Yu Zhilong Z Wu Jinsong J Qiu Zhengjun Z

American journal of translational research 20210215 2

Long intergenic noncoding RNAs (lincRNAs) are strongly associated with several kinds of cancer, including gastric cancer. Here, we found significantly decreased lincRNA-01317 levels in cancer tissue compared with paracancer tissue of patients with gastric cancer, and lincRNA-01317 expression levels positively correlated with clinical survival rate. Furthermore, using a gastric cancer cell line and a xenograft mouse model, we found that transfection of a gastric cancer cell line with lincRNA-0131 ...[more]

PMID: 33594325

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