The influence of chemical composition, aerosol acidity, and metal dissolution on the oxidative potential of fine particulate matter and redox potential of the lung lining fluid.

ABSTRACT: Air pollution is a major environmental health risk and it contributes to respiratory and cardiovascular diseases and excess mortality worldwide. The adverse health effects have been associated with the inhalation of fine particulate matter (PM_2.5) and induction of respiratory oxidative stress. In this work, we quantified the oxidative potential (OP) of PM_2.5 from several Canadian cities (Toronto, Hamilton, Montreal, Vancouver) using a recently developed bioanalytical method which measures the oxidation of lung antioxidants, glutathione, cysteine, and ascorbic acid, the formation of glutathione disulfide and cystine, and the related redox potential (RP) in a simulated epithelial lining fluid (SELF). We evaluated the application of empirical SELF RP as a new metric for

SUBMITTER: Shahpoury P 

PROVIDER: S-EPMC7868889 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature