Reorganization of Metabolism during Cardiomyogenesis Implies Time-Specific Signaling Pathway Regulation.

ABSTRACT: Understanding the cell differentiation process involves the characterization of signaling and regulatory pathways. The coordinated action involved in multilevel regulation determines the commitment of stem cells and their differentiation into a specific cell lineage. Cellular metabolism plays a relevant role in modulating the expression of genes, which act as sensors of the extra-and intracellular environment. In this work, we analyzed mRNAs associated with polysomes by focusing on the expression profile of metabolism-related genes during the cardiac differentiation of human embryonic stem cells (hESCs). We compared different time points during cardiac differentiation (pluripotency, embryoid body aggregation, cardiac mesoderm, cardiac progenitor and cardiomyocyte) and showed the immature c

SUBMITTER: Barison MJ 

PROVIDER: S-EPMC7869011 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature