Tau and Amyloid Relationships with Resting-state Functional Connectivity in Atypical Alzheimer's Disease.

ABSTRACT: The mechanisms through which tau and amyloid-beta (Aβ) accumulate in the brain of Alzheimer's disease patients may differ but both are related to neuronal networks. We examined such mechanisms on neuroimaging in 58 participants with atypical Alzheimer's disease (posterior cortical atrophy or logopenic progressive aphasia). Participants underwent Aβ-PET, longitudinal tau-PET, structural MRI and resting-state functional MRI, which was analyzed with graph theory. Regions with high levels of Aβ were more likely to be functional hubs, with a high number of functional connections important for resilience to cascading network failures. Regions with high levels of tau were more likely to have low clustering coefficients and degrees, suggesting a lack of trophic support or vulnerability to local ne

SUBMITTER: Sintini I 

PROVIDER: S-EPMC7869088 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature