Pathways for Contextual Memory: The Primate Hippocampal Pathway to Anterior Cingulate Cortex.

ABSTRACT: The anterior cingulate cortex (ACC) is one of the few prefrontal areas that receives robust direct hippocampal terminations. This pathway may enable current context and past experience to influence goal-directed actions and emotional regulation by prefrontal cortices. We investigated the still ill-understood organization of the pathway from anterior hippocampus to ACC (A24a, A25, A32) to identify laminar termination patterns and their postsynaptic excitatory and inhibitory targets from system to synapse in rhesus monkeys. The densest hippocampal terminations targeted posterior A25, a region that is involved in affective and autonomic regulation. Hippocampal terminations innervated mostly excitatory neurons (~90%), suggesting strong excitatory effects. Among the smaller fraction of inhibito

SUBMITTER: Wang J 

PROVIDER: S-EPMC7869091 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature