Selective treatment pressure in colon cancer drives the molecular profile of resistant circulating tumor cell clones.

ABSTRACT: The characterization of circulating tumor cells (CTCs) holds promises for precision medicine because these cells are an important clinical indicator of treatment efficacy. We established the first and still only nine permanent colon CTC lines from peripheral blood samples of a patient with metastatic colon cancer collected at different time points during treatment and cancer progression. The study objectives were (i) to compare the gene expression profiles of these CTC lines, and (ii) to determine the main features acquired during treatment. The number of upregulated genes was higher in the CTC lines obtained after treatment, indicating that they acquired properties to escape treatment pressure. Among these upregulated genes, some are involved in the mTOR and PI3K/AKT signaling pathways. M

SUBMITTER: Cayrefourcq L 

PROVIDER: S-EPMC7869222 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature