Quantitative proteomics analysis of lysine 2-hydroxyisobutyrylation in IgA nephropathy.

ABSTRACT:

Background

Protein posttranslational modification is an indispensable regulatory element that can fine-tune protein functions and regulate diverse cellular processes. Lysine 2-hydroxyisobutyrylation (Khib) is a protein posttranslational modification that was recently identified and is thought to play a role in a wide variety of active cellular functions.

Methods

In this report, for the first time, we comparatively studied the 2-hydroxyisobutyrylation proteome in peripheral blood mononuclear cells from a biopsy-proven immunoglobulin A nephropathy (IgAN) group and a normal control group based on liquid chromatography-tandem mass spectrometry.

Results

Altogether, 7405 proteins were identified and added to a Khib library. Of these proteins, we identified 111 with upregula

SUBMITTER: Huang S 

PROVIDER: S-EPMC7869230 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature