Crystal structure of the non-steroidal anti-inflammatory drug (NSAID) tolmetin sodium.

ABSTRACT: The asymmetric unit of the title compound, sodium 2-[1-methyl-5-(4-methyl-benzo-yl)-1H-pyrrol-2-yl]acetate dihydrate, Na⁺·C₁₅H₁₄NO₃ ^-·2H₂O, contains two sodium cations, two organic anions (A and B) and two water mol-ecules. The coordination geometry around the sodium cations corresponds to a distorted octa-hedron. Each pair of sodium cations (A-A or B-B) is chelated by two bridging anions coordinated by the O atoms of the deprotonated carb-oxy-lic groups, and each sodium atom is coordinated by an O atom of a third anion, which connects pairs of sodium atoms, and a water mol-ecule. As a result, a two-dimensional polymer is formed in the crystal. Hirshfeld surface analysis and t

SUBMITTER: Konovalova IS 

PROVIDER: S-EPMC7869531 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature