High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma.

ABSTRACT: Pancreatic cancer ranks one of the worst in overall survival outcome with a 5 year survival rate being less than 10%. Pancreatic cancer faces unique challenges in its diagnosis and treatment, such as the lack of clinically validated biomarkers and the immensely immunosuppressive tumor microenvironment. Recently, the LY6 gene family has received increasing attention for its multi-faceted roles in cancer development, stem cell maintenance, immunomodulation, and association with more aggressive and hard-to-treat cancers. A detailed study of mRNA expression of LY6 gene family and its association with overall survival (OS) outcome in pancreatic cancers is lacking. We used publicly available clinical datasets to analyze the mRNA expression of a set of LY6 genes and its effect on OS outcome in th

SUBMITTER: Russ E 

PROVIDER: S-EPMC7869573 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature