Microbiome changes associated with acute and chronic pancreatitis: A systematic review.

ABSTRACT:

Background

Altered intestinal microbiota has been reported in pancreatic disorders, however, it remains unclear whether these changes alter the course of disease in patients with acute (AP) and chronic pancreatitis (CP), or whether these disease states alter the environment to enable pathogenic microbial composition changes to occur. We undertook a systematic review to characterize the gut microbiome in pancreatitis patients.

Methods

MEDLINE and EMBASE were searched for studies on microbiota in pancreatitis published from January 1, 2000 to June 5, 2020. Animal studies, reviews, case reports, and non-English articles were excluded. A frequency analysis was performed for outcomes reported in ≥2 studies and studies were analyzed for risk of bias and quality of evidence.

Res

SUBMITTER: Brubaker L 

PROVIDER: S-EPMC7869754 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature