Identification and characterization of two classes of G1 β-bulge.

ABSTRACT: In standard β-bulges, a residue in one strand of a β-sheet forms hydrogen bonds to two successive residues (`1' and `2') of a second strand. Two categories, `classic' and `G1' β-bulges, are distinguished by their dihedral angles: 1,2-α_Rβ_R (classic) or 1,2-α_Lβ_R (G1). It had previously been observed that G1 β-bulges are most often found as components of two quite distinct composite structures, suggesting that a basis for further differentiation might exist. Here, it is shown that two subtypes of G1 β-bulges, G1α and G1β, may be distinguished by their conformation (α_R or β_R) at residue `0' of the second strand. β-Bulges that are constituents of the composite structure named the β-bulge loop are of the G1α type, whereas those th

SUBMITTER: Leader DP 

PROVIDER: S-EPMC7869896 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature