Structure-functional relationship of cellular retinoic acid-binding proteins I and II interacting with natural and synthetic ligands.

ABSTRACT: A detailed understanding of the interactions between small-molecule ligands and their proposed binding targets is of the utmost importance for modern drug-development programs. Cellular retinoic acid-binding proteins I and II (CRABPI and CRABPII) facilitate a number of vital retinoid signalling pathways in mammalian cells and offer a gateway to manipulation of signalling that could potentially reduce phenotypes in serious diseases, including cancer and neurodegeneration. Although structurally very similar, the two proteins possess distinctly different biological functions, with their signalling influence being exerted through both genomic and nongenomic pathways. In this article, crystal structures are presented of the L29C mutant of Homo sapiens CRABPI in complex with naturally occurring

SUBMITTER: Tomlinson CWE 

PROVIDER: S-EPMC7869897 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature