Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET.

ABSTRACT:

Purpose

Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic pain and neuroinflammation, which may contribute to the multifactorial pathological mechanisms in both FM and CRPS. The aim of this study was to assess neuroinflammation in FM patients compared with that in patients with CRPS and healthy controls.

Methods

Neuroinflammation was measured as the distribution volume ratio (DVR) of [11C]-(R)-PK11195 positron emission tomography (PET) in 12 FM patients, 11 patients with CRPS and 15 healthy controls.

Results

Neuroinflammation in FM patients was significantly higher in the left pre (primary motor cortex) and post (primary somatosensory cortex) central gyri (p < 0.001), right postcentral gyrus (p < 0.005),

SUBMITTER: Seo S 

PROVIDER: S-EPMC7870009 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature