Gut microbiota comparison of vaginally and cesarean born infants exclusively breastfed by mothers secreting α1-2 fucosylated oligosaccharides in breast milk.

ABSTRACT:

Background

Exclusive breastfeeding promotes beneficial modifications on the microbiota of cesarean born infants, but little is known about the role of specific breast milk components in this modulation. Women with an active FUT2 gene (called secretors) secrete α1-2 fucosylated human milk oligosaccharides (HMOs), which promote Bifidobacterium in the infant's gut and may modulate the microbiota of cesarean born infants.

Objective

To compare the microbiota composition of cesarean and vaginally born infants breastfed by secretor mothers.

Methods

Maternal secretor status was determined by the occurrence of 4 different α1-2 fucosylated HMOs in breast milk by LC-MS. The fecal microbiota composition from cesarean and vaginally born infants was analyzed by 16S rRNA gene sequen

SUBMITTER: Tonon KM 

PROVIDER: S-EPMC7870049 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature