Clinical significance of potential drug-drug interactions in a pediatric intensive care unit: A single-center retrospective study.

ABSTRACT: Despite the high prevalence of potential drug-drug interactions in pediatric intensive care units, their clinical relevance and significance are unclear. We assessed the characteristics and risk factors of clinically relevant potential drug-drug interactions to facilitate their efficient monitoring in pediatric intensive care units. This retrospective cohort study reviewed the medical records of 159 patients aged <19 years who were hospitalized in the pediatric intensive care unit at Seoul National University Hospital (Seoul, Korea) for ≥3 days between August 2019 and February 2020. Potential drug-drug interactions were screened using the Micromedex Drug-Reax® system. Clinical relevance of each potential drug-drug interaction was reported with official terminology, magnitude of severity, a

SUBMITTER: Choi YH 

PROVIDER: S-EPMC7870058 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature