Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation.

ABSTRACT: The emergence of antibiotic resistance over the past several decades has given urgency to new antibacterial strategies that apply less selective pressure. A new class of anti-virulence compounds were developed that are active against methicillin-resistant Staphylococcus aureus (MRSA), by inhibiting bacterial virulence without hindering their growth to reduce the selective pressure for resistance development. One of the compounds CCG-211790 has demonstrated potent anti-biofilm activity against MRSA. This new class of anti-virulence compounds inhibited the gene expression of virulence factors involved in biofilm formation and disrupted the biofilm structures. In this study, the physicochemical properties of CCG-211790, including morphology, solubility in pure water or in water containing sod

SUBMITTER: Wang N 

PROVIDER: S-EPMC7870075 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature