Using Network Pharmacology to Explore the Mechanism of Peach Kernel-Safflower in the Treatment of Diabetic Nephropathy.

ABSTRACT:

Objective

The mechanism of peach kernel-safflower in treating diabetic nephropathy (DN) was investigated using network pharmacology.

Methods

Network pharmacology methodology was applied to screen the effective compounds of peach kernel-safflower in the SymMap and TCMSP databases. Potential targets were then screened in the ETCM, SEA, and SymMap databases to construct a compound-target network. This was followed by screening of DN targets in OMIM, Gene, and GeneCards databases. The common targets of drugs and diseases were selected for analysis in the STRING database, and the results were imported into Cytoscape 3.8.0 to construct a protein-protein interaction network. Next, GO and KEGG enrichment analyses were performed. Finally, Schrödinger molecular docking verified the re

SUBMITTER: Han J 

PROVIDER: S-EPMC7870307 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature