Exercise Limitation in Children and Adolescents With Severe Refractory Asthma: A Lack of Asthma Control?

ABSTRACT:

Background

Patients with severe refractory asthma (SRA), even when using high doses of multiple controller medications in a regular and appropriate way, can have persistent complaints of exercise limitation.

Methods

This was a cross-sectional study involving patients with SRA (treated with ≥ 800 μg of budesonide or equivalent, with ≥ 80% adherence, appropriate inhaler technique, and comorbidities treated), who presented no signs of a lack of asthma control other than exercise limitation. We also evaluated healthy controls, matched to the patients for sex, age, and body mass index. All participants underwent cardiopulmonary exercise testing (CPET) on a cycle ergometer, maximum exertion being defined as ≥ 85% of the predicted heart rate, with a respiratory exchange ratio ≥ 1.0

SUBMITTER: Faleiro RC 

PROVIDER: S-EPMC7870485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature