Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model.

ABSTRACT: Pancreatic cancer has the worst prognosis of all cancers due to disease aggressiveness and paucity of early detection platforms. We developed biomaterial scaffolds that recruit metastatic tumor cells and reflect the immune dysregulation of native metastatic sites. While this platform has shown promise in orthotopic breast cancer models, its potential in other models is untested. Herein, we demonstrate that scaffolds recruit disseminated pancreatic cells in the KPCY model of spontaneous pancreatic cancer prior to adenocarcinoma formation (3-fold increase in scaffold YFP + cells). Furthermore, immune cells at the scaffolds differentiate early- and late-stage disease with greater accuracy (0.83) than the natural metastatic site (liver, 0.50). Early disease was identified by an approximately 2

SUBMITTER: Bushnell GG 

PROVIDER: S-EPMC7870556 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature