Ex vivo machine perfusion: current applications and future directions in liver transplantation.

ABSTRACT:

Background

Liver transplantation is the only curative treatment option for end-stage liver disease; however, its use remains limited due to a shortage of suitable organs. In recent years, ex vivo liver machine perfusion has been introduced to liver transplantation, as a means to expand the donor organ pool.

Purpose

To present a systematic review of prospective clinical studies on ex vivo liver machine perfusion, in order to assess current applications and highlight future directions.

Methods

A systematic literature search of both PubMed and ISI web of science databases as well as the ClinicalTrials.gov registry was performed.

Results

Twenty-one articles on prospective clinical trials on ex vivo liver machine perfusion were identified. Out of these, eight report

SUBMITTER: Michelotto J 

PROVIDER: S-EPMC7870621 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature