Differential longitudinal changes of neuronal and glial damage markers in anorexia nervosa after partial weight restoration.

ABSTRACT: Atrophic brain changes in acute anorexia nervosa (AN) are often visible to the naked eye on computed tomography or magnetic resonance imaging scans, but it remains unclear what is driving these effects. In neurological diseases, neurofilament light (NF-L) and tau protein have been linked to axonal damage. Glial fibrillary acidic protein (GFAP) has been associated with astroglial injury. In an attempt to shed new light on factors potentially underlying past findings of structural brain alterations in AN, the current study investigated serum NF-L, tau protein, and GFAP levels longitudinally in AN patients undergoing weight restoration. Blood samples were obtained from 54 acutely underweight, predominantly adolescent female AN patients and 54 age-matched healthy control participants. AN patie

SUBMITTER: Hellerhoff I 

PROVIDER: S-EPMC7870648 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature