Coordinated co-migration of CCR10⁺ antibody-producing B cells with helper T cells for colonic homeostatic regulation.

ABSTRACT: In the intestine, IgA antibody-secreting B cells (IgA-ASCs) and helper T cells coordinate to maintain local homeostasis while their dysregulation could lead to development of intestinal inflammatory diseases. However, mechanisms underlying the coordinated localization and function of the B and T cells into the intestine, particularly the colon, are poorly understood. We herein report the first evidence that the gut-homing chemokine receptor CCR10⁺ IgA-ASCs form conjugates with helper T cells, preferentially regulatory T cells, at their differentiation sites of gut-associated lymphoid organs for their coordinated co-localization into the colon to promote local homeostasis. In CCR10-knockout mice, defective migration of IgA-ASCs also resulted in defective T-cell migration and home

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7870723 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature