Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.

ABSTRACT:

Purpose

Berzosertib (formerly M6620) is the first-in-class inhibitor of ataxia-telangiectasia and Rad3-related protein, a key component of the DNA damage response, and being developed in combination with chemotherapy for the treatment of patients with advanced cancers. The objectives of this analysis were to characterize the pharmacokinetics (PK) of berzosertib across multiple studies and parts, estimate inter-individual variability, and identify covariates that could explain such variability.

Methods

A population PK analysis was performed using the combined dataset from two phase I clinical studies (NCT02157792, EudraCT 2013-005100-34) in patients with advanced cancers receiving an intravenous infusion of berzosertib alone or in combination with chemotherapy. The analysis i

SUBMITTER: Terranova N 

PROVIDER: S-EPMC7870753 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature