Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?

ABSTRACT: Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The predictive power of zebrafish embryos for general vertebrate teratogenicity strongly depends on the correlation between fish and mammals with respect to both overall general toxicity and more specific endpoints indicative of certain modes-of-action. The present study was designed to analyze the correlation between (1) effects of valproic acid and nine of its analogues in zebrafish embryos and (2) their known neurodevelopmental effects in mice. To this end, zebrafish embryos exp

SUBMITTER: Brotzmann K 

PROVIDER: S-EPMC7870776 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature